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ctss  (R&D Systems)


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    Structured Review

    R&D Systems ctss
    Gene expression analysis to identify candidate genes encoding novel host environment factors supporting grafted neurons. (A) Schematic flowchart describing the selection process of candidate genes. (B-H) Gene expression levels of the 7 candidate genes selected, as represented by count per million, for (B) Apod , <t>(C)</t> <t>Ctsd</t> , (D) <t>Ctss</t> , (E) Lyz2 , (F) Spp1 , (G) Grn , and (H) Sparc . Data are represented as the mean ± SEM, n = 4, Mann-Whitney test; * P < .05.
    Ctss, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 29 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+human+ctss/Recombinant+Human+Cathepsin+S+Protein%2C+CF/pmc11555480-53-36-38
    Average 93 stars, based on 29 article reviews
    ctss - by Bioz Stars, 2026-10
    93/100 stars

    Images

    1) Product Images from "Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons"

    Article Title: Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons

    Journal: Stem Cells Translational Medicine

    doi: 10.1093/stcltm/szae066

    Gene expression analysis to identify candidate genes encoding novel host environment factors supporting grafted neurons. (A) Schematic flowchart describing the selection process of candidate genes. (B-H) Gene expression levels of the 7 candidate genes selected, as represented by count per million, for (B) Apod , (C) Ctsd , (D) Ctss , (E) Lyz2 , (F) Spp1 , (G) Grn , and (H) Sparc . Data are represented as the mean ± SEM, n = 4, Mann-Whitney test; * P < .05.
    Figure Legend Snippet: Gene expression analysis to identify candidate genes encoding novel host environment factors supporting grafted neurons. (A) Schematic flowchart describing the selection process of candidate genes. (B-H) Gene expression levels of the 7 candidate genes selected, as represented by count per million, for (B) Apod , (C) Ctsd , (D) Ctss , (E) Lyz2 , (F) Spp1 , (G) Grn , and (H) Sparc . Data are represented as the mean ± SEM, n = 4, Mann-Whitney test; * P < .05.

    Techniques Used: Gene Expression, Selection, MANN-WHITNEY

    Related Articles

    Recombinant:

    Article Title: Rational design of humanized antibody inhibitors for cathepsin S.
    Article Snippet: Cathepsin S (CTSS) is involved in pathogenesis of many human diseases.. Inhibitors blocking its protease activity hold therapeutic potential.. In comparison to small-molecule inhibitors, monoclonal antibodies capable of inhibiting CTSS enzymatic activity may possess advantageous pharmacological properties.

    Article Title: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay
    Article Snippet: A biodegradable gelatin hydrogel sheet (MedGel PI5; MedGel, Osaka, Japan) was soaked with 100 μL of drugs following the manufacturer’s procedure and applied onto the site of the IAN injury under 2% isoflurane inhalation. .. Clophosome-A (Clo: 700 μg/100 μL, F70101C-A, FormuMax Scientific, CA, USA), control liposome (Lipo: 100 μL, F70101-A, FormuMax Scientific), saline (100 μL), recombinant human CTSS (rhCTSS: 0.2 μg/100 μL in saline, 1183-CY-010, R&D systems, MN, USA), rhCTSS + Clo, or rhCTSS + Ephrin-B2 blocking peptide (EBP; GTX88049-PEP, Genetex, CA, USA [rhCTSS: 0.2 μg + EBP: 10 μg/100 μL in saline]) were applied 2 day post-IANX. .. Z-FL-COCHO (Z-FL, a CTSS-specific inhibitor: 10 pmol/100 μL in the vehicle, AOB13823, AOBIOUS, MA, USA) or vehicle were administered 2 and 8 day post-IANX.

    Article Title: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast-Schwann cell-signaling relay.
    Article Snippet: A biodegradable gelatin hydrogel sheet (MedGel PI5; MedGel, Osaka, Japan) was soaked with 100 μL of drugs following the manufacturer’s procedure and applied onto the site of the IAN injury under 2% isoflurane inhalation. .. Clophosome-A (Clo: 700 μg/100 μL, F70101C-A, FormuMax Scientific, CA, USA), control liposome (Lipo: 100 μL, F70101-A, FormuMax Scientific), saline (100 μL), recombinant human CTSS (rhCTSS: 0.2 μg/100 μL in saline, 1183-CY-010, R&D systems, MN, USA), rhCTSS + Clo, or rhCTSS + Ephrin-B2 blocking peptide (EBP; GTX88049-PEP, Genetex, CA, USA [rhCTSS: 0.2 μg + EBP: 10 μg/100 μL in saline]) were applied 2 day post-IANX. .. Z-FL-COCHO (Z-FL, a CTSS-specific inhibitor: 10 pmol/100 μL in the vehicle, AOB13823, AOBIOUS, MA, USA) or vehicle were administered 2 and 8 day post-IANX.

    Control:

    Article Title: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay
    Article Snippet: A biodegradable gelatin hydrogel sheet (MedGel PI5; MedGel, Osaka, Japan) was soaked with 100 μL of drugs following the manufacturer’s procedure and applied onto the site of the IAN injury under 2% isoflurane inhalation. .. Clophosome-A (Clo: 700 μg/100 μL, F70101C-A, FormuMax Scientific, CA, USA), control liposome (Lipo: 100 μL, F70101-A, FormuMax Scientific), saline (100 μL), recombinant human CTSS (rhCTSS: 0.2 μg/100 μL in saline, 1183-CY-010, R&D systems, MN, USA), rhCTSS + Clo, or rhCTSS + Ephrin-B2 blocking peptide (EBP; GTX88049-PEP, Genetex, CA, USA [rhCTSS: 0.2 μg + EBP: 10 μg/100 μL in saline]) were applied 2 day post-IANX. .. Z-FL-COCHO (Z-FL, a CTSS-specific inhibitor: 10 pmol/100 μL in the vehicle, AOB13823, AOBIOUS, MA, USA) or vehicle were administered 2 and 8 day post-IANX.

    Article Title: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast-Schwann cell-signaling relay.
    Article Snippet: A biodegradable gelatin hydrogel sheet (MedGel PI5; MedGel, Osaka, Japan) was soaked with 100 μL of drugs following the manufacturer’s procedure and applied onto the site of the IAN injury under 2% isoflurane inhalation. .. Clophosome-A (Clo: 700 μg/100 μL, F70101C-A, FormuMax Scientific, CA, USA), control liposome (Lipo: 100 μL, F70101-A, FormuMax Scientific), saline (100 μL), recombinant human CTSS (rhCTSS: 0.2 μg/100 μL in saline, 1183-CY-010, R&D systems, MN, USA), rhCTSS + Clo, or rhCTSS + Ephrin-B2 blocking peptide (EBP; GTX88049-PEP, Genetex, CA, USA [rhCTSS: 0.2 μg + EBP: 10 μg/100 μL in saline]) were applied 2 day post-IANX. .. Z-FL-COCHO (Z-FL, a CTSS-specific inhibitor: 10 pmol/100 μL in the vehicle, AOB13823, AOBIOUS, MA, USA) or vehicle were administered 2 and 8 day post-IANX.

    Saline:

    Article Title: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay
    Article Snippet: A biodegradable gelatin hydrogel sheet (MedGel PI5; MedGel, Osaka, Japan) was soaked with 100 μL of drugs following the manufacturer’s procedure and applied onto the site of the IAN injury under 2% isoflurane inhalation. .. Clophosome-A (Clo: 700 μg/100 μL, F70101C-A, FormuMax Scientific, CA, USA), control liposome (Lipo: 100 μL, F70101-A, FormuMax Scientific), saline (100 μL), recombinant human CTSS (rhCTSS: 0.2 μg/100 μL in saline, 1183-CY-010, R&D systems, MN, USA), rhCTSS + Clo, or rhCTSS + Ephrin-B2 blocking peptide (EBP; GTX88049-PEP, Genetex, CA, USA [rhCTSS: 0.2 μg + EBP: 10 μg/100 μL in saline]) were applied 2 day post-IANX. .. Z-FL-COCHO (Z-FL, a CTSS-specific inhibitor: 10 pmol/100 μL in the vehicle, AOB13823, AOBIOUS, MA, USA) or vehicle were administered 2 and 8 day post-IANX.

    Article Title: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast-Schwann cell-signaling relay.
    Article Snippet: A biodegradable gelatin hydrogel sheet (MedGel PI5; MedGel, Osaka, Japan) was soaked with 100 μL of drugs following the manufacturer’s procedure and applied onto the site of the IAN injury under 2% isoflurane inhalation. .. Clophosome-A (Clo: 700 μg/100 μL, F70101C-A, FormuMax Scientific, CA, USA), control liposome (Lipo: 100 μL, F70101-A, FormuMax Scientific), saline (100 μL), recombinant human CTSS (rhCTSS: 0.2 μg/100 μL in saline, 1183-CY-010, R&D systems, MN, USA), rhCTSS + Clo, or rhCTSS + Ephrin-B2 blocking peptide (EBP; GTX88049-PEP, Genetex, CA, USA [rhCTSS: 0.2 μg + EBP: 10 μg/100 μL in saline]) were applied 2 day post-IANX. .. Z-FL-COCHO (Z-FL, a CTSS-specific inhibitor: 10 pmol/100 μL in the vehicle, AOB13823, AOBIOUS, MA, USA) or vehicle were administered 2 and 8 day post-IANX.

    Blocking Assay:

    Article Title: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay
    Article Snippet: A biodegradable gelatin hydrogel sheet (MedGel PI5; MedGel, Osaka, Japan) was soaked with 100 μL of drugs following the manufacturer’s procedure and applied onto the site of the IAN injury under 2% isoflurane inhalation. .. Clophosome-A (Clo: 700 μg/100 μL, F70101C-A, FormuMax Scientific, CA, USA), control liposome (Lipo: 100 μL, F70101-A, FormuMax Scientific), saline (100 μL), recombinant human CTSS (rhCTSS: 0.2 μg/100 μL in saline, 1183-CY-010, R&D systems, MN, USA), rhCTSS + Clo, or rhCTSS + Ephrin-B2 blocking peptide (EBP; GTX88049-PEP, Genetex, CA, USA [rhCTSS: 0.2 μg + EBP: 10 μg/100 μL in saline]) were applied 2 day post-IANX. .. Z-FL-COCHO (Z-FL, a CTSS-specific inhibitor: 10 pmol/100 μL in the vehicle, AOB13823, AOBIOUS, MA, USA) or vehicle were administered 2 and 8 day post-IANX.

    Article Title: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast-Schwann cell-signaling relay.
    Article Snippet: A biodegradable gelatin hydrogel sheet (MedGel PI5; MedGel, Osaka, Japan) was soaked with 100 μL of drugs following the manufacturer’s procedure and applied onto the site of the IAN injury under 2% isoflurane inhalation. .. Clophosome-A (Clo: 700 μg/100 μL, F70101C-A, FormuMax Scientific, CA, USA), control liposome (Lipo: 100 μL, F70101-A, FormuMax Scientific), saline (100 μL), recombinant human CTSS (rhCTSS: 0.2 μg/100 μL in saline, 1183-CY-010, R&D systems, MN, USA), rhCTSS + Clo, or rhCTSS + Ephrin-B2 blocking peptide (EBP; GTX88049-PEP, Genetex, CA, USA [rhCTSS: 0.2 μg + EBP: 10 μg/100 μL in saline]) were applied 2 day post-IANX. .. Z-FL-COCHO (Z-FL, a CTSS-specific inhibitor: 10 pmol/100 μL in the vehicle, AOB13823, AOBIOUS, MA, USA) or vehicle were administered 2 and 8 day post-IANX.



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    Gene expression analysis to identify candidate genes encoding novel host environment factors supporting grafted neurons. (A) Schematic flowchart describing the selection process of candidate genes. (B-H) Gene expression levels of the 7 candidate genes selected, as represented by count per million, for (B) Apod , <t>(C)</t> <t>Ctsd</t> , (D) <t>Ctss</t> , (E) Lyz2 , (F) Spp1 , (G) Grn , and (H) Sparc . Data are represented as the mean ± SEM, n = 4, Mann-Whitney test; * P < .05.
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    Image Search Results


    Gene expression analysis to identify candidate genes encoding novel host environment factors supporting grafted neurons. (A) Schematic flowchart describing the selection process of candidate genes. (B-H) Gene expression levels of the 7 candidate genes selected, as represented by count per million, for (B) Apod , (C) Ctsd , (D) Ctss , (E) Lyz2 , (F) Spp1 , (G) Grn , and (H) Sparc . Data are represented as the mean ± SEM, n = 4, Mann-Whitney test; * P < .05.

    Journal: Stem Cells Translational Medicine

    Article Title: Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons

    doi: 10.1093/stcltm/szae066

    Figure Lengend Snippet: Gene expression analysis to identify candidate genes encoding novel host environment factors supporting grafted neurons. (A) Schematic flowchart describing the selection process of candidate genes. (B-H) Gene expression levels of the 7 candidate genes selected, as represented by count per million, for (B) Apod , (C) Ctsd , (D) Ctss , (E) Lyz2 , (F) Spp1 , (G) Grn , and (H) Sparc . Data are represented as the mean ± SEM, n = 4, Mann-Whitney test; * P < .05.

    Article Snippet: The concentrations of each recombinant human protein were as follows: apolipoprotein D, APOD (NBP1-99548; Novus Biologicals, Centennial, CO, USA), 250, 500 mg/dL; cathepsin D, Ctsd (1014-AS-010; R&D Systems, Minneapolis, MN, USA), 250, 500 mg/dL; cathepsin S, Ctss (1183-CY-010; R&D Systems, Minneapolis, MN, USA), 250, 500 mg/dL; lysozyme, LYZ (ab158839; abcam, Cambridge, UK), 250, 500 mg/dL; osteopontin, OPN (1433-OP-050 CF; R&D Systems, Minneapolis, MN, USA), 250, 500 mg/dL, progranulin, PGRN (2420-PG-050; R&D Systems, Minneapolis, MN, USA), 5, 10 μg/mL; secreted protein acidic and cysteine rich, SPARC (941-SP-050; R&D Systems, Minneapolis, MN, USA), 500, 1000 mg/dL.

    Techniques: Gene Expression, Selection, MANN-WHITNEY